CRP and chronic obstructive pulmonary disease: Future strategies may also include the establishment of clear and detailed criteria for selecting patients who are suitable for macrolide prophylaxis in COPD guidelines, [33] introduction of point-of-care testing of C-reactive protein, which has been shown to reduce antibiotic use among patients with COPD exacerbations by identifying those unlikely to benefit from antibiotic therapy [34], and the use of novel macrolides with anti-inflammatory effects but no antibiotic effects which could reduce COPD exacerbations but not lead to increases in antibiotic resistance [35].