ESR2 and cancer: Among different clinical and pathological parameters of the studied CRC cases, a comparative analysis in this study showed significant association between loss of ER expression and depth of invasion (p= 0.01), similar to Wong et al., (2005) who found that lower ER beta expression was associated with higher pT stage and it is in agreement with Hartman et al., (2009); Rudolph et al., (2012) and Ferlay et al., (2012) who found that lack of ER beta expression is associated with advanced cancer stages in CRC.