Among different clinical and pathological parameters of the studied CRC cases, a comparative analysis in this study showed significant association between loss of ER expression and depth of invasion (p= 0.01), similar to Wong et al., (2005) who found that lower ER beta expression was associated with higher pT stage and it is in agreement with Hartman et al., (2009); Rudolph et al., (2012) and Ferlay et al., (2012) who found that lack of ER beta expression is associated with advanced cancer stages in CRC. This evidence concerns the gene ESR2 and colorectal carcinoma.