Estrogen receptor beta (ERβ) is by far the predominant isoform in the colon mucosa (Campbell-Thompson et al., 2001; Konstantinopoulos et al., 2003; Wong et al., 2005) and its expression is lost during the progression of colon cancer (Foley et al., 2000; Wada-Hiraike et al., 2006). Here, ESR2 is linked to malignant colon neoplasm.