Several HER2-targeted therapeutic strategies have potential to adopt the HER2 overexpression tumor cells: monoclonal antibodies downregulate HER2 expression by binding to the extracellular domain (such as trastuzumab and pertuzumab); antibody-drug conjugates (such as trastuzumab emtansine, called T-DM1); and tyrosine kinase inhibitors (such as lapatinib and neratinib), which compete for ATP-binding to block HER2 signaling (Di Modica et al., 2017). The gene discussed is ERBB2; the disease is neoplasm.