EGFR and esophageal cancer: Similar strong correlations between digital image score (quantitative method) and pathologist visual scoring (objective method) have been described in different tissue types other than breast including epidermal growth factor receptor signaling molecule in colorectal cancer (Messersmith et al., 2005), cell-free DNA level in ovarian cancer (Rizzardi et al., 2012), DNA mismatch repair protein in esophageal cancer (Alexander et al., 2012) and prognostic value of changes in quality life scores in prostate cancer (Braun et al., 2013).