Few years later, in another study by Bredholt et al., (2009) apoptosis was observed in khat methonolic extract (200μg/mL)-treated human acute myeloid leukemia cell lines (MOLM-13) (p<0.05) and the process was mediated through c-FLIPL cleavage and procaspase-8 activation. The gene discussed is CFLAR; the disease is acute myeloid leukemia.