BRCA1 and breast cancer: Results of the studies included in this review which considered the role of BRCA mutation in BC risk indicated that women with BC and a BRCA1 mutation had an earlier age of disease onset, higher nuclear grade of BC, and a younger age of hospitalization (Chen et al., 2013a; Liu et al., 2013b; Pei et al., 2014; Sun et al., 2014a; Fu et al., 2015; Haryono et al., 2015; Wu et al., 2015) when compared to those without the BRCA mutation.