Increased BC risk was associated with insulin use for 3 or more years (mortality risk) among participants from Thailand (Tseng, 2015); polycystic ovary syndrome (Shen et al., 2015); tonsillectomy (Sun et al., 2015a); sleep apnea (Chang et al., 2014); multiple sclerosis among participants from Taiwan (Sun et al., 2014c); inflammatory bowel disease among participants from Asia (Tsai et al., 2015); women who had an organ transplant (Pan et al., 2013); and diabetes among participants from China (Wang et al., 2013b). This evidence concerns the gene INS and multiple sclerosis.