It would also be important to investigate the prognostic value of adding other metastasis predictors to statistical models, such as BAP1, PRAME, SF3B1, and EIF1AX. Although these factors are known to be associated with metastatic disease from uveal melanoma, it cannot be assumed that they improve prognostication in comparison with models using only LBTD and C3S or only LBTD and gene expression profiling. The gene discussed is PRAME; the disease is metastatic neoplasm.