Interestingly, disrupting the interaction between GR, FKBP4, and FKBP5 is associated with cognitive impairment and depressive disorders (Fujii et al., 2014; Simic et al., 2013; Tatro, Everall, Kaul, & Achim, 2009). The gene discussed is NR3C1; the disease is Cognitive impairment.