Although only one case of LOH at the AIP locus (11q13) in FTCs is previously described [27], Daly et al. recently described an FTC in a teenaged AIP mutation-positive carrier in which decreased AIP staining was seen in the FTC tumor that was accompanied by LOH at the AIP locus in the tumor DNA [28]. This evidence concerns the gene AIP and thyroid cancer, nonmedullary, 2.