CXCL12, NLRC3, Wnt/β-catenin target genes including BAMBI, BOP1, CKS2 and NFIL3, as well as miRNA-135b, Linc00659 and CRNDE are associated with the proliferation, invasion or metastasis of CRC cells via PI3K/AKT signaling [125–130]. This evidence concerns the gene LINC00659 and colorectal carcinoma.