Anyway, the overall genetic alterations of PIK3CA (0.4%), PIK3R1 (0.5%), PIK3R2 (0.1%), AKT1 (0.1%), AKT2 (0.1%) and PTEN (1.1%, Table 1) are observed statistically in NHL. This evidence concerns the gene PIK3CA and non-Hodgkin lymphoma.