Some p110α isoform-selective inhibitors, such as A66 or PIK-75, could effectively suppress the GBM cell growth, survival and migration in vitro [24], while inhibition of p110β by TGX-221 only arrests cell migration, and inhibition of p110δ by IC87114 or CAL-101 moderately blocks cell proliferation and migration [22, 25]. This evidence concerns the gene PIK3CD and glioblastoma.