The overall genetic alterations of PI3K/AKT pathway in CRC are observed as follows: PIK3CA (22%), PIK3R1 (5%), PIK3R2 (2.2%), AKT1 (1.8%), AKT2 (2.5%) and PTEN (8%, Table 1). The gene discussed is PIK3R1; the disease is colorectal carcinoma.