Furthermore, another subtype of EOC, ovarian clear cell carcinomas (OCCCs), shows more frequently mutations of PIK3CA (33%) and PTEN (5%) in overall 97 OCCC cases, especially mutations of PIK3CA (46%) in the 28 cases of affinity purified OCCCs and OCCC cell lines [192], than the mutation of PIK3CA and PTEN (both < 5%) in HGOSC [193]. Here, PTEN is linked to ovarian clear cell cancer.