REC8, TEKT4, ING5, c-Met, HPIP, PIG3, TBX1, CRLF1, INPP4B, MAPK4, miR-34a, -125b, -126, -145, -146b, -148a and -766, as well as lncRNA LINC003121, ABHD11-AS1, H19 and XIST regulate TC cell growth, tumor progression, migration, metastasis or epithelial–mesenchymal transition (EMT) through activating PI3K/AKT pathway [41–61]. Here, MAPK4 is linked to neoplasm.