Apparently, two specific lymphomas, FL and DLBCL, account for about 65% of all NHL, and more importantly, the genomic profile of transformed FL shares similarities with that of GCB de novo DLBCL, and thus a thorough knowledge of these two entities related with PI3K/AKT pathway is essential [307–309]. The gene discussed is AKT1; the disease is non-Hodgkin lymphoma.