Furthermore, dual PI3K/mTOR inhibitors are effective at inducing apoptosis in primary OS cell cultures in vitro in both human and mouse OS, while specific PI3K or mTOR inhibitors are not effective [370], which is consistent with the preclinical study’s result that BEZ235 inhibits proliferation and tumor development of OS cells in vivo [371]. Here, PIK3CG is linked to neoplasm.