On the other hand, top to 70% of patients with breast cancer brain metastases (BCBM) show the activated PI3K pathway [170], and GDC-0084 induces apoptosis of PIK3CA-mutant BCBM cells by suppressing activation of AKT and p70 S6 kinase [171]. The gene discussed is PIK3CG; the disease is breast carcinoma.