Based on the data presented herein, we conclude that MG1363-pMG36e-GLP-1 attenuates neuroinflammation via down-regulating TLR4/NF-κB pathway, up-regulated the AKT/GSK3β signaling pathway, and restore the disturbed microbiota to normal level, so as to reduce the spatial learning and memory disorders of AD mice and the ability of movement and exploration of PD mice. This evidence concerns the gene TLR4 and Alzheimer disease.