In the open field assessment, PD mice had reduced the average movement speed (1.16 s vs. 4.5 s), the distance in the central area (95.73 cm vs. 343.1 cm) and the duration of movement in the central area (4.67 s vs. 17.1 s) versus the control group (p < 0.001; Fig. 1e–g), and treatment with MG1363-pMG36e-GLP-1 had significantly improved the behavioral performance compared with mice in PD group (p < 0.001; Fig. 1e–g). The gene discussed is GCG; the disease is Parkinson disease.