Hepatic arterial infusion of bevacizumab can achieve significantly more reduction in tumor volume and decreasement in cell proliferation than systemic administration of bevacizumab for colorectal liver metastasis in rat model [16].Theoretically, arterial infusion of anti-PD-1 antibody for hepatic metastases has the potential to achieve higher drug concentration for tumoral infiltrative lymphocytes (TILs) than the intravenous route, which may be translated into improved anti-tumor immune response. Here, PDCD1 is linked to neoplasm.