To further address the role of DDX11 in HCC progression, we employed the gain-of-function strategy and both protein and mRNA levels of DDX11 were markedly increased in Hep3B or Huh7 cells after transfecting with pcDNA-DDX11 (oe-DDX11) (Supplementary Fig. 5A). The gene discussed is DDX11; the disease is hepatocellular carcinoma.