HGF and colorectal carcinoma: MethCORR map analysis of the signatures revealed two distinct patterns within the TME cluster: The CRC-113, ColoGuideEX, and Oncotype DX signatures associated with a CAF-like pattern (Figs. 3e, f, and 4b), cancer invasiveness and hepatocyte growth factor (HGF) expression41 (Fig. 4c, d).