In addition, the combined anti-PD-1/G007-LK treatment also reduced WNT/β-catenin signaling and tumor volume of murine Clone M-3Z1 melanoma in immunocompetent DBA/2 N mice (Fig. 3b, Supplementary Figs. 11a, c-f and 29). This evidence concerns the gene PDCD1 and neoplasm.