AKT1 and breast neoplasm: We found negative correlations between FOXO3 protein expression and protein expressions of Phospho-S6K (Thr-421/Ser-424) (r = −0.252, p = 2.10−4), Phospho-S6K (Thr-389) (r = −0.163, p = 1.6.10−2), Phospho-S6 (Ser-235/Ser-236) (r = −0.186, p = 5.8.10−3), and Phospho-S6 (Ser-24) (r = −0.301, p < 10−4), suggesting that the low expression of FOXO3 protein is associated to a weak activity of the PI3K/AKT/mTOR pathway in breast tumors.