IFNγ+ T cells in established TNBS-colitis mice were rich in CD81+ T cells at 3.7-fold (12.8% versus 3.5%) or 4.9-fold (6.4% versus 1.3%) compared with CD81− T cells with or without SEB stimulation, respectively (Supplementary Figs. 7 and 9). Here, SETBP1 is linked to colitis.