CD81 and colitis: To further examine the effect of the anti-CD81 antibody on intestinal inflammation, mice with established TNBS-induced colitis were intraperitoneally injected with the anti-mouse CD81 antibody (clone 2F7) once a day for 6 days, and changes in the colitis score and body weight were examined for 28 days until colitis symptoms had diminished (Fig. 3, Supplementary Fig. 4a and Supplementary Table 1).