NEDD4L and idiopathic pulmonary fibrosis: Totally, 547 proteins were differentially expressed in lungs of conditional Nedd4-2−/− mice (P < 0.05) and 322 proteins were changed in lung tissues of IPF patients compared to their respective controls (P < 0.05) with a substantial overlap of 104 differentially detected proteins between conditional Nedd4-2−/− mice and patients with IPF (Fig. 7a–c).