Moreover, we found that, in aMCI individuals and AD patients, lower hippocampal level of NLGN1 significantly correlates with higher hippocampal level of soluble Aβ (p < 0.01; Fig. 1B) as well as with poorer cognitive state assessed with the MMSE (p < 0.01; Fig. 1C). This evidence concerns the gene NLGN1 and Alzheimer disease.