HNF1B and renal cell carcinoma: Besides the known developmental disorders and syndromes associated with inactivating mutations in the HNF1B gene9,10, there is evidence that HNF1B expression is associated with the tumorigenesis of several types of solid tumours, especially in the subset of clear cell carcinomas of the ovary (OCCC)6,7 and renal cell carcinomas (RCC) of the kidney11.