The content of P-selectin in the hyperthyroidism model group (4.82 ± 0.81 ng/L), H + low iodine group (4.43 ± 0.64 ng/L) and the endothelial injury group (6.66 ± 0.79 ng/L) was higher than that in the control group (3.77 ± 0.36 ng/L, P < 0.05). This evidence concerns the gene SELP and hyperthyroidism.