Compared to the control group, the serum levels of vWF in the hyperthyroidism model group (457.75 ± 29.06 ng/L), the H + low iodine group (412.77 ± 28.74 ng/L), the high iodine group (495.36 ± 39.58 ng/L) and the endothelial injury group (402.84 ± 31.61 ng/L) were significantly higher (P < 0.05). The gene discussed is VWF; the disease is hyperthyroidism.