Compare to the levels of acetylated WT, the mutant FOXL2s, I80T and W204X, which are found in the type I BPES patients, showed markedly decreased acetylation, and similar levels of acetylation were found in the N109K FOXL2 mutant, which is associated with the type II BPES (Supplementary Fig. 17a). Here, FOXL2 is linked to blepharophimosis, ptosis, and epicanthus inversus syndrome.