FOXL2 and blepharophimosis, ptosis, and epicanthus inversus syndrome: We selected and cloned the following FOXL2 mutants found in BPES patients based on the human FOXL2 mutation database40: Q53X, I80T, I84S, F167X, and W204X, found in type I BPES patients showing both POI and eyelid malformation, and N105S and N109K, found in type II BPES patients exhibiting eyelid malformation, but not POI (Fig. 7a).