FOXL2 is highly expressed in the ovaries and eyelids, and autosomal dominant germline mutations in FOXL2 cause blepharophimosis, ptosis epicanthus inversus syndrome (BPES) manifested by an eyelid malformation and primary ovarian insufficiency (POI)20. The gene discussed is FOXL2; the disease is blepharophimosis, ptosis, and epicanthus inversus syndrome.