Our data highlight the therapeutic potential of the IRE1α branch of the UPR, and converge on the notion that in Zika virus-infected human and mouse embryos, the UPR was observed in the cerebral cortex of postmortem fetuses, and the IRE1α nuclease inhibitor 4μ8C reduced the microcephaly frequency74. The gene discussed is ERN1; the disease is microcephaly.