Finally, we tested the non-viral delivery of adenine base editor to the liver of a mouse model of Tyrosinemia I. Tyrosinemia I mice harbor a homozygous G•C to A•T point mutation in the last nucleotide of exon 8 in the Fah gene, causing exon 8 skipping, FAH protein deficiency, and liver damage. The gene discussed is FAH; the disease is hyperinsulinemic hypoglycemia, familial, 4.