However, it is worth emphasizing that we did not find congenital muscular atrophy or obvious myopathies in the PFM of 1-month-old TH-null mice (Fig. 7j and Supplementary Fig. 1b), which indicates that CACNA1H is not necessary in muscle development, or there is a possible compensatory effect in the organism during muscle development. The gene discussed is TH; the disease is muscular atrophy.