CRLF2 and acute lymphoblastic leukemia: Additionally, the main molecular characteristics of BCR-ABL1-like ALL are the multiple translocations in different cytokine receptor and kinase signaling genes such as ABL1 (excluding BCR association), JAK2, ABL2, PDGFRB, TYK2, CSF1R, CRLF2, and EPOR. These mutations trigger the activation of growth promoting kinase or cytokine signaling pathways14.