Statistically significant differences were found in the rate of JAK/STAT mutations between BCR-ABL1-like patients and the remaining B-other ALL patients [BCR-ABL1-like 9/14 (64%) vs 3/28 (11%), P = 0.001], but not for RAS genes or lymphoid transcription factors. Here, SOAT1 is linked to acute lymphoblastic leukemia.