TP53 and neoplasm: In mutp53 knockin mice small molecule inhibitors targeting Hsp90 (e.g. 17AAG, Ganetespib) and/or its positive regulator HDAC6 (e.g. SAHA) degrade stabilized mutp53 in tumor tissues and markedly extend survival in a mutp53-specific manner, since they have no benefit in p53 null mice15,16.