Comparison of their expression in HUVEC and HT-29, a human colorectal carcinoma cell line, revealed that RIPK1 and MLKL were expressed in HUVEC and HT29, while RIPK3 was normally expressed in HT29 but at an extremely low level in HUVEC (Fig. 1b, c). Here, RIPK1 is linked to colorectal carcinoma.