Oikawa et al have suggested that ND1+32656 GG and IL-8-251 T/T alleles may increase the risk of erosive esophagitis, even in an H. pylori-infected Japanese population.[19] Yucel has reported that the symptoms of gastroesophageal reflux disease improve after eradication of H. pylori in patients with antral gastritis and duodenal ulcers that have hyperacidity.[20] Although our patient had clinical remission, the third EGD still revealed persistent esophageal injury. Here, CXCL8 is linked to duodenal ulcer.