Our data suggest that anti-CSPG4 and PDD may be a suitable antibody and payload combination for the development of an anti-CSPG4-(PDD) ADC with potent target antigen-specific cytotoxic functions via the ability to trigger apoptotic cell death in CSPG4-expressing melanoma cells, whilst the ADC lacked off-target or Fc-mediated cytotoxic effects. This evidence concerns the gene CSPG4 and melanoma.