Recently, we also demonstrated that the residual tumor left after si-VDAC1 inhibition of tumor growth, exhibited a reversal of the oncogenic properties, such as reprogramed metabolism, angiogenesis, epithelial–mesenchymal transition (EMT), invasiveness, and stemness, leading to differentiation into neuron- and astrocyte-like cells [49]. Here, VDAC1 is linked to neoplasm.