PTEN and neoplasm: Particularly it was seen to play a key role in the apoptotic signaling of the tumor cell through direct stimulation of caspases cascade and the inhibition of the anti-apoptotic pathways such as PTEN/PI3K/AKT, Sirt-1, AMPK/YAP, NF-κB and STAT3 that contribute to tumor cell immortality [75,76,77,78,79,80].