PTGS2 and cancer: It has been proven that HUR protein is overexpressed in CRC, is associated with the activation of COX2 and VEGFA gene expression in tumor endothelial cells and, therefore, is an important factor activating angiogenesis in tumor cells and plays an important role in cancer development and progression by targeting the mRNAs of proto-oncogenes, cytokines, growth and invasion factors [23,24,25,26,48,49].