The overexpression of COX2 has been observed in multiple cancers, including CRC, and can induce the expression of VEGF, leading to increased angiogenesis and tumor progression [34,35], while AU-rich element-binding (ARE) proteins HUR and CUGBP2 have been shown to stabilize and modulate COX2 expression [36]. This evidence concerns the gene CELF2 and colorectal carcinoma.