STAT3 and systemic lupus erythematosus: All the above mentioned plant-derived phyto-molecules exert their anti-SLE effect by one means or the other, such as (i) nitric oxide synthase (iNOS) and COX-2 inhibitors; (ii) autoantibody production inhibitors; (iii) lymphocyte proliferation inhibitors; (iv) NFκB and NFAT-mediated signaling inhibitors; (v) STAT3, CREMα and Rho-associated protein kinase (ROCK) inhibitors; (vi) pro-inflammatory cytokine production regulators; and (vii) symptomatic relief providers.