Remarkably, given the critical role played by Kv1.1 channels in dampening neuronal excitability, the opportunity to target Kv1.1 appears as a fruitful strategy to treat Kv1.1-associated diseases and brain disorders not linked to KCNA1 abnormalities that are caused by neuronal hyperexcitability. The gene discussed is KCNA1; the disease is brain disorder.