Indeed, spontaneous epileptic activity has been reported in both the Kv1.1S309T/+ mice (carrying the missense mutation S309T in the S4 of Kv1.1 channels) [105] and the megalencephaly mice, mceph/mceph (in which a frameshift mutation in the KCNA1 gene leads to a truncated non-functional protein) [106]. Here, KCNA1 is linked to megalencephaly.