As mentioned before, kcna1 knock-out mice mimic several of the risk factors observed in human SUDEP such as young age, high seizures frequency, and seizure-evoked cardiac and respiratory abnormalities; for this reason, these mice are widely used to study the pathogenesis of SUDEP in epilepsy as well as to test the therapeutic potential of drugs proposed for seizure remission and neuroprotection. This evidence concerns the gene KCNA1 and epilepsy.