CAFs in human breast cancer biopsies were shown to be rich in HSF1, and the depletion of HSF1 led to a loss of the factors transforming growth factor-β (TGF-β) and CXCL12/SDF1 known to program the tumor microenvironment in a pro-tumorigenic and metastatic manner [50]. The gene discussed is HSF1; the disease is breast cancer.