HSP90AA1 and cancer: There is indeed considerable evidence for the participation of many of the HSPs in cancer, particularly Hsp27, Hsp70, and Hsp90, and the TRiC/CCT chaperonins, which are elevated in many tumor types and play roles in most of the processes that determine the tumor phenotype, including growth, evasion of death and senescence pathways, invasion, metastasis, and stemness [11,57,193].