CD36-mediated ox-LDL also triggers CEBP-β expression to directly upregulate Nogo-B and promote lipophagy, causing lysophosphatidic acid-enhanced yes-associated protein 1 (YAP) oncogenic activity, which subsequently induces carcinogenetic signaling for NAFLD-associated HCC [2]. The gene discussed is YAP1; the disease is metabolic dysfunction-associated steatotic liver disease.