EZH2 and neoplasm: In non-small-lung cancer, studies show that PAGBC promotes tumor cell proliferation via its ability to serve as a scaffold lncRNA for EZH2 and LSD1 [160], whereas in colorectal cancer, PAGBC acts as a tumor-suppressive lncRNA through direct binding to SRSF6, a serine-arginine-rich splicing factor that is involved in various RNA associated processes.