NFE2L2 and kidney disorder: Additionally, in kidney disease models such as autoimmune nephritis [56], diabetic nephropathy [57,58,59], toxic injury [60,61,62], ureteral obstruction [63], podocyte injury [64] and IRI [61,63,64,65,66,67], the loss of Nrf2 aggravates tissue damage and fibrosis (Table 1).