Figure 4 and Figure 5 describe generic models of how the macroenvironment of bulk adipose promotes and drives the development of oncogenesis through endocrine and paracrine signalling. As the cytokines/adipocytokines [92,196,200,203,204] act as stimulatory activators of both canonical and non-canonical STAT3 signalling this drives multiple processes (described in preceding sections) that rely on nuclear and mitochondrial interplay that result in promoting STAT3 addiction and cancer. The gene discussed is STAT3; the disease is cancer.