LEP and cancer: While adiponectin signaling functionally inhibits CPT1 activity (Figure 3), and has been correlated with of inhibition of STAT3 signalling in cancer, the differential expression of adiponectin receptors in the presence of leptin may reduce this inhibition, allowing for STAT3 mediation of adipocytokine signalling and promotion of breast cancer phenotypes allowing adipose tissue to create a fostering niche for cancer to thrive [230,231,232].