STAT3 and cancer: In addition to Y705P, STAT3 can also undergo several other post-translational modifications such as phosphorylation on S727 in oncogenic transformation [79,80], lysine acetylation or methylation and cysteine oxidation or glutathionylation in starved cancer cells stimulated with serum or insulin, and in cardiomyocytes as part of reduction-oxidation (REDOX) regulation [81,82,83].