When considering the leptin activation (see Figure 3—Adipocytokine signaling pathway) of the JAK/STAT3 pathway, STAT3 directly upregulates FAO through transcriptional activation of carnitine palmitoyltransferase 1B (CPT1B) in breast cancer stem cells; promoting stemness and chemoresistance [107]. The gene discussed is STAT3; the disease is breast carcinoma.