STAT3 and B-cell chronic lymphocytic leukemia: In chronic lymphocytic leukaemia (CLL) cells, although both pS727 STAT3 and pY705 STAT3 activate the transcription of the same repertoire of genes, constitutively activated pS727 STAT3 not only activated anti-apoptotic genes, but also shows low-affinity binding to the caspase-3 promoter [169].