ADCYAP1 and amyotrophic lateral sclerosis: To better characterize the effect of PACAP in ALS motor neuron degeneration, in the present study we investigated its involvement in the autophagy process by using an in vitro model of neuroblastoma-spinal cord-34 (NSC-34) cells stably bearing a human Cu/Zn superoxide dismutase1 G93A mutation (G93A) exposed to hypoxic insult.