MAPK3 and breast cancer: A decrease in viability of the human breast cancer triple negative MDA-MB-231 cells by PROP was also described at 100 and 200 μM concentrations, arresting cell cycle progression at G0/G1 and S phase and inducing cell apoptosis by inhibiting the activation of ERK1/2 and the expression of cyclo-oxygenase 2 [40].