DAXX and Alpha-thalassemia: Exon sequencing of paediatric HGGs identified recurrent somatic mutations (K27M, G34R/V) in histone H3 [7,8] and inactivating mutations in the Death-domain associated protein/Alpha thalassemia-mental retardation (DAXX/ATRX) genes, leading to DNA hypomethylation [9,10,11].