GPT and central nervous system cancer: ALT, an alternative mechanism to maintain telomere length based on homologous recombination, is found mostly in tumors with a mesenchymal origin (sarcomas) and in a subset of malignant pediatric brain tumors [1], including High Grade Glioma (HGG, 51%), Diffuse Intrinsic Pontine Glioma (DIPG) (18%), Choroid Plexus Carcinoma (CPC) (22.6%), and Primitive Neuroectodermal Tumors (PNET) (11.6%) [2,3].