CXCL13 and Lyme disease: Our review offers an updated analysis of studies, including publications by Halperin and Rupprecht et al., which presents an overview of the diagnosis and management of neuroborreliosis and neurosyphilis and whose authors suggest a potential role of chemokine ligand 13 (CXCL13) as an accurate diagnostic marker of these two spirochetal infections of the nervous system [2,5,6,7,8,9,10,11,12,13].