Of interest, mRNA Seq analysis of myxoma-derived cells show that miR-126-3p up-regulation in these cells when compared with normal hCSCs is associated with specular down-regulation of several genes involved with cell cycle/growth and in particular of plexin-B2 (PLXNB2) (Supplementary material online, Figure S4C), which has been recently shown to play a key role in growth, survival and regenerative capabilities of normal haematopoietic and leukaemic stem and progenitor cells.47 Here, PLXNB2 is linked to myxoma.