CEBPA and leukemia: Myeloid lineage commitment is important for leukemogenesis, as Cebpa mutant leukemias are propagated by committed myeloid progenitors (Bereshchenko et al., 2009, Kirstetter et al., 2008) whose self-renewal is dramatically increased by loss of C/EBPα-mediated E2F repression (Porse et al., 2005), and requires the p30 isoform, which retains the SWI/SNF binding domain critical for activation of C/EBP-dependent myeloid lineage genes (Pedersen et al., 2001).