The loss of myeloid and gain of erythroid TF chromatin access in the presence of Gata2 ZnF1 mutation may be relevant to the myeloid differentiation block characteristic of AML, and in particular act cooperatively with altered TF gene expression induced by biallelic Cebpa mutation, providing a molecular basis for the correlation of CEBPA and GATA2 mutation in AML. Here, GATA2 is linked to acute myeloid leukemia.