ASPH and cancer: Considering that AspH is translocated to the cell membrane of invasive cancer cells,19 the dicarboxylic acid motif of the 2,4‐PDCA derivatives synthesised might be beneficial to minimise the cell‐wall permeability of the inhibitors and thus reducing the possibility of undesired off‐target effects through inhibiting other 2OG oxygenases, such as the Jmjc KDMs, in cells.