Crystallographic analysis of the active site structures of the two types of 2OG oxygenases suggest that it should be possible to develop selective inhibitors for AspH or the KDM4 class of 2OG oxygenases.23, 43 Now that a reliable assay for isolated AspH has been established24 and Jmjc KDMs including KDM4E are actively being pursued as medicinal chemistry targets with several pyridine‐based and related small‐molecule inhibitors for cancer treatment,44 AspH should be included in Jmjc KDM selectivity counter‐screens in order to develop improved inhibitors and safe medicines. Here, ASPH is linked to cancer.