In PCOS group, FBG (1.965, 95% CI [0.70–9.04]), log fasting insulin (10.650, 95% CI [96.89–855.06]), log HOMA-IR (- 11.598, 95% CI [- 866.33—- 106.15]) and serum hs-CRP (- 0.321, 95% CI [- 10.09—- 3.24]) significantly predicted serum Metrnl (P < 0.05). This evidence concerns the gene INS and polycystic ovary syndrome.