The pathogenesis of PCOS shares several features with metabolic syndrome (MetS), including dysfunctional adipose tissue with visceral adiposity, impaired insulin action with an increased risk for developing type II diabetes mellitus (T2DM), pro-atherogenic dyslipidemia, non-alcoholic fatty liver disease (NAFLD), and metaflammation [11–14]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.