While the aberrant expression of p63 confers a myriad of tumor cell-intrinsic phenotypes in PDA, such as enhanced motility, invasion, and resistance to cytotoxic chemotherapy (Danilov et al., 2011; Somerville et al., 2018), our work points to a powerful non cell-autonomous effect of p63 in PDA in promoting stromal inflammation. The gene discussed is TP63; the disease is neoplasm.