Finally, plasma concentrations of the murine cytokine IL-6, a marker of systemic inflammation and immunosuppression (Flint et al., 2016; Nishimoto and Kishimoto, 2006) that is largely produced by iCAFs in PDA (Biffi et al., 2019; Elyada et al., 2019; Öhlund et al., 2017), were ~10 fold higher in the mice bearing SUIT2-p63 versus SUIT2-empty tumors (Figure 3—figure supplement 1U). This evidence concerns the gene IL6 and Patent ductus arteriosus.