S100A2 and cancer: In the human cancer cell compartment, we identified 633 genes that were significantly upregulated in SUIT2-p63 tumors compared to controls, which largely corresponded to squamous lineage p63 target genes (e.g. S100A2, KRT5) (Figure 3D, Figure 3—figure supplement 1L and Supplementary file 3; Bailey et al., 2016; Somerville et al., 2018).