TP63 and neoplasm: By monitoring tumor progression using bioluminescent imaging, we found that p63 inactivation resulted in a significant reduction in tumor growth when compared to control tumors (Figure 4A–B), which is consistent with in vivo-specific growth enhancement caused by acute p63 expression in SUIT2 and mM1 orthotopic models (Figure 3A–B and Figure 3—figure supplement 1A–K).