Importantly, an analysis of p63 over-expression and knockout/knockdown RNA-seq datasets performed in nine different human PDA lines or organoids (Somerville et al., 2018) revealed that this group of inflammatory genes is regulated by p63 across these different contexts, albeit with a degree of heterogeneity (Figure 5D and Figure 5—figure supplement 1C). Here, TP63 is linked to Patent ductus arteriosus.