Given that IL-6 is a well known inflammatory cytokine that promotes B-cell proliferation occurring during bone marrow stimulation, the authors postulated that this creates a “feed-forward cytokine amplification loop” in which the tumor environment becomes ideal for plasma cell neoplasm progression.11 The trauma of any sort can trigger injured cells to secrete these inflammatory cytokines, which can sometimes lead to plasmacytoma development. This evidence concerns the gene IL6 and plasma cell neoplasm.